Th2 Cytokines Act on S100/A11 to Downregulate Keratinocyte Differentiation
نویسندگان
چکیده
منابع مشابه
Th2 Cytokines Suppress Lipoteichoic Acid Induced Matrix Metalloproteinase Expression and Keratinocyte Migration in Response to Wounding
Recent clinical trials have established a central role for the Th2 cytokines IL-4 and IL-13 in the pathology of atopic dermatitis (AD) (Beck et al., 2014). Although blockade of the IL-4 and IL-13 receptors causes significant clearing of skin lesions, a direct effect of Th2 cytokines on wound healing processes has not yet been demonstrated. Furthermore, AD patients are frequently affected by inf...
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background: the aim of this study was to determine the th1 and th2 serum cytokines, in patients with psoriasis and to com pare their cytokine levels with those of normal control subjects. methods: serum levels of interferon-gamma (ifn-γ), interleukin-2 (il-2), interleukin-4 (il-4), and interleukin-10 (il-10) were measured by enzyme linked immunosorbent assay in 40 patients with psoriasis and in...
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Atopic dermatitis (AD), a chronic relapsing inflammatory skin disease, is increasing in prevalence around the world. Intensive research is ongoing to understand the mechanisms involved in the development of AD and offer new treatment options for patients suffering from AD. In this review, we highlight the importance of allergic Th2 responses in the development of the disease and summarize relev...
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Growth/differentiation control of normal epithelial cells has been relatively understudied, because of the complexities involved in their cultivation and characterization. The present review is focused on progress in this area using the mouse primary keratinocyte system. This system reproduces under well defined culture conditions the switch between epithelial cell growth and differentiation wh...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2008
ISSN: 0022-202X
DOI: 10.1038/jid.2008.74